DESCRIPTION

• Mw: 83.8 kDa
• Tag: Myc-DDK
• Accn: NM_001007792
• Type: Human Tagged ORF Clone Lentiviral Particle
• Refseq: NM_001007792.1, NP_001007793.1
• Status: 2 Weeks*
• Symbol: TrkA
• Vector: pLenti-C-Myc-DDK
• Category: cDNA Clones
• Locus Id: 4914
• Orf Size: 2280 bp
• Synonyms: MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
• Refseq Orf: 2283 bp
• Uniprot Id: P04629
• Refseq Size: 2581 bp
• Availability: 2 Weeks
• Cytogenetics: 1q23.1
• Gene Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
• Sequence Data: ORF Nucleotide Sequence ( show hide ) The ORF insert of this clone is exactly the same as(RC220855).
• Oti Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Oti Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer
• Mammalian Cell Selection: None