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E0991Hu

Human Androgen Receptor, AR ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed: 20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.

DETAILS

  • GeneID: 367
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 99,188
  • Synonyms: Androgen receptor;AR;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: AR
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.095ng/ml
  • Target Protein: AR
  • Detection Range: 0.2-70ng/ml
  • Full Product Name: Androgen Receptor
  • Standard Solution: 80ng/ml
  • UniProt Accession: P10275