SOX2 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6657
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SOX2
Other Names: Transcription factor SOX-2, SOX2
Availability: 2 weeks
Bio Background: This intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Bio References: Remenyi, A., et al., Genes Dev. 17(16):2048-2059 (2003).Wiebe, M.S., et al., J. Biol. Chem. 278(20):17901-17911 (2003).Fantes, J., et al., Nat. Genet. 33(4):461-463 (2003).Schepers, G.E., et al., Dev. Cell 3(2):167-170 (2002).Kamachi, Y., et al., Trends Genet. 16(4):182-187 (2000).
Other Accession: NP_003097
Primary Accession: P48431
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2048a was selected from the N-term region of human SOX2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.