30-2468
Anti-CD19 Monoclonal Antibody (Clone:LT19)-PE/DyLight Conjugated
Abeomics
DESCRIPTION
CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
DETAILS
- Gene: CD19
- App Id: FACS, IP
- Antigen: CD19
- Gene Id: 930
- Isotype: Mouse IgG1
- Clone Name: LT19
- Uniprot Id: P15391
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: PE/DyLight
- Reactivity Id: Human
- Alternative Name: CD19
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Daudi human Burkitt lymphoma cell line