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T9088

Topovale

TargetMol

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DETAILS

  • Cas: 500214-53-9
  • Purity: 99.94%
  • Smiles: C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5
  • Category: Compound
  • Molecular Weight: 421.45
  • Molecular Formula: C23H23N3O5

DESCRIPTION

Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.

Lead Time: 4 - 5 weeks

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