Alexa Fluor™ 555-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining

DESCRIPTION

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Source: Alexa Fluor 555-Labeled Human GUCY2C Protein, His Tag (GUC-HA2H6) is produced via conjugation of AF555 to Human GUCY2C Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human GUCY2C Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1).
Storage: -20℃, aviod light
Category: Fluorescent labeled protein
Molecule: GUCY2C
Conjugate: AF555 Labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ser 24 - Gln 430
Swiss-prot: P25092-1
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.9 kDa.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 62.9 kDa
Shipping Condition: RT
Species Reactivity: Human
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