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Animal-Free Recombinant Human IFN-gamma



IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-gamma is a 16.8 kDa protein containing 144 amino acid residues.


  • Gene Id: 3458
  • Uniprot: P01579.1
  • Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: AIDS/HIV, Angiogenesis/Cardiovascular, Cancer, Diabetes/Weight Regulation, Immune System, Neurobiology, Stem Cells and Differentiation, Allergy, Transplantation, COVID-19
  • Alternative Names: Immune Interferon, type II interferon, T cell interferon, MAF
  • Species of Origin: Human
  • Expression System Source: E.coli