mouse monoclonal IgG1; CKR-2B Antibody (A-11) is an IgG1 κ mouse monoclonal CKR-2B antibody (also designated C-C Motif Chemokine Receptor 2 antibody, CC-CKR-2 antibody, MCP-1-R antibody, Monocyte Chemoattractant Protein 1 Receptor antibody, C-C Chemokine Receptor Type 2 antibody, CMKBR2 antibody, CCR-2 antibody, CD192 antibody, CKR2 antibody, Monocyte Chemotactic Protein 1 Receptor antibody, MCP-1 Receptor antibody, CD192 Antigen antibody, C-C CKR-2 antibody, CCR2A antibody, CCR2B antibody, CKR2A antibody, or CKR2B antibody) that detects the CKR-2B protein of human origin by WB, IP, IF and ELISA. CKR-2B Antibody (A-11) is available as both the non-conjugated anti-CKR-2B antibody form, as well as multiple conjugated forms of anti-CKR-2B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. C-C or b chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-8, CKR-9, CKR-10 and the Duffy blood group antigen. Each of these receptors are G protein coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. CKR-2 (C-C chemokine receptor type 2) is a 374 amino acid multi-pass membrane protein that belongs to the C-C chemokine receptor family and is expressed as two isoforms, designated CKR-2A and CKR-2B. Both CKR-2 isoforms function as receptors for a variety of proteins, including MCP-1 and MCP-3, thereby influencing intracellular calcium levels and affecting signal transduction throughout the cell.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.