SB525334

DESCRIPTION

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.

DETAILS

Iupac: 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
Smiles: CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
Aliases: SB525334; SB-525334; SB 525334
Cas Number: 356559-20-1
Molecular Weight: 343.42494
Molecular Formula: C21H21N5