Human VSIG3 Protein, Fc Tag

DESCRIPTION

VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 1mg
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
Format: Powder
Purity: 95%
Source: Human VSIG3, Fc Tag (VS3-H5258) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 241 (Accession # Q5DX21-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: VSIG3
Accession: NP_001015887.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Leu 23 - Gly 241
Swiss-prot: Q5DX21-1
Package Size: 500ug*2
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 49.7 kDa
Shipping Condition: RT
Species Reactivity: Human
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