LY3177833

DESCRIPTION

An inhibitor of Cdc7 kinase (IC50 = 3.3 nM); inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 µM); LY3177833 reduces tumor growth in an SW620 mouse xenograft model at 10, 20, and 30 mg/kg twice per day

DETAILS

Inchi: InChI=1S/C16H12FN5O/c1-16(14-13(17)7-18-8-19-14)12-3-2-9(10-5-20-21-6-10)4-11(12)15(23)22-16/h2-8H,1H3,(H,20,21)(H,22,23)/t16-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling
Smiles: O=C1N[C@](C2=NC=NC=C2F)(C)C3=CC=C(C4=CNN=C4)C=C31
Inchikey: KNLVLWZENYQYRT-MRXNPFEDSA-N
Cas Number: 1627696-51-8
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C16H12FN5O
Formula Weight: 309.3
Shelf Life Days: 1460