T11807
L002
TargetMol
DESCRIPTION
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.
DETAILS
- Cas: 321695-57-2
- Purity: 98.59%
- Smiles: N(OS(=O)(=O)C1=CC=C(OC)C=C1)=C2C=C(C)C(=O)C(C)=C2
- Category: Compound
- Molecular Weight: 321.35
- Molecular Formula: C15H15NO5S
Lead Time: 4 - 5 weeks
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