DESCRIPTION

• Form: Concentrated tissue culture supernatant
• Gene: PRPH
• Host: Mouse
• Rrid: AB_2492207
• Type: Primary Antibody
• Clone: 7C5
• Buffer: Concentrated tissue culture supernatant + 10 mM NaN3
• Target: Peripherin
• Isotype: IgG1
• Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
• Shipping: Blue Ice
• Synonyms: NEF 4 antibody, NEF4 antibody, Neurofilament 4 (57kD) antibody, Neurofilament 4 antibody, Perf antibody, PERI_HUMAN antibody, Peripherin antibody, PRPH 1 antibody, prph antibody, PRPH1 antibody
• Clonality: Monoclonal
• Immunogen: Recombinant rat peripherin expressed in and purified from E. coli.
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for endogenous levels of the ~57 kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.
• Applications: WB, IHC, ICC
• Ncbi Gene Id: 3414
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Quality Control: Western blots performed on each lot.
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 57
• Production Notes: Concentrated tissue culture supernatant
• Dilution Range Wb: 1:1000
• Immunogen Species: Rat
• Dilution Range Icc: 1:200-1:500
• Dilution Range Ihc: 1:200
• Species Reactivity: Mouse and Rat
• Target Description: Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
• Dilution Range Wb Brain: 1:1000
• Uniprot Number Immunogen Species: P21807

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