Human Endoglin / CD105 Protein, His Tag

DESCRIPTION

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 500ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human BST1, His Tag (ENN-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Gly 586 (Accession # P17813-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: Endoglin
Accession: NP_001108225.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Glu 26 - Gly 586
Swiss-prot: P17813-1
Package Size: 500ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.6 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 62.6 kDa
Shipping Condition: RT
Species Reactivity: Human
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