PD1-H82A4-25ug PD1-H82A4-200ug
Biotinylated Human PD-1 / PDCD1 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
ACROBiosystems
Image
![](https://www.acrobiosystems.com/static/main/products/images/sds/PD1-H82A4.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PD1-H82A4-E1.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PD1-H82A4-E2.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PD1-H82A4-E1.jpg)
DESCRIPTION
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
DETAILS
- Tag: C-mFc(mIgG2a) & C-Avi
- Host: HEK293
- Size: 200ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 95%
- Source: Biotinylated Human PD-1, Mouse IgG2a Fc,Avitag (PD1-H82A4) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # Q15116-1).
- Storage: -20℃
- Category: MABSol® Biotin Labeled Proteins
- Molecule: PD-1
- Accession: NP_005009.2
- Conjugate: Biotin-labeled
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Leu 25 - Gln 167
- Swiss-prot: Q15116-1
- Package Size: 200ug*1
- Characteristics: This protein carries a mouse IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.5 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 44.5 kDa
- Shipping Condition: RT
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html