GD5-M5149-100ug GD5-M5149-1mg
Mouse GDF-15 / MIC-1 Protein, His Tag
ACROBiosystems
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DESCRIPTION
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
DETAILS
- Tag: N-10×His
- Host: E. coli
- Size: 1mg
- Buffer: 0.085%TFA 30%ACN
- Format: Powder
- Purity: 90%
- Source: Mouse GDF-15, His Tag (GD5-M5149) is expressed from E. coli cells. It contains AA Ser 189 - Ala 303 (Accession # Q9Z0J7-1).
- Storage: -20℃
- Category: Bio-Markers & CD Antigens
- Molecule: GDF-15
- Accession: NP_035949.2
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Ser 189 - Ala 303
- Swiss-prot: Q9Z0J7-1
- Package Size: 250ug*4
- Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.6 kDa. The protein migrates as 16-17 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 14.6 kDa
- Shipping Condition: RT
- Species Reactivity: Mouse
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html