Mouse GDF-15 / MIC-1 Protein, His Tag

DESCRIPTION

Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.

DETAILS

Tag: N-10×His
Host: E. coli
Size: 1mg
Buffer: 0.085%TFA 30%ACN
Format: Powder
Purity: 90%
Source: Mouse GDF-15, His Tag (GD5-M5149) is expressed from E. coli cells. It contains AA Ser 189 - Ala 303 (Accession # Q9Z0J7-1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: GDF-15
Accession: NP_035949.2
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ser 189 - Ala 303
Swiss-prot: Q9Z0J7-1
Package Size: 250ug*4
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.6 kDa. The protein migrates as 16-17 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 14.6 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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