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29623

Talniflumate

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
  • Smiles: O=C1C2=CC=CC=C2C(OC(C3=CC=CN=C3NC4=CC(C(F)(F)F)=CC=C4)=O)O1
  • Inchikey: ANMLJLFWUCQGKZ-UHFFFAOYSA-N
  • Cas Number: 66898-62-2
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C21H13F3N2O4
  • Formula Weight: 414.3
  • Shelf Life Days: 1460

DESCRIPTION

A prodrug form of niflumic acid; decreases the rate of chloride/bicarbonate exchange in isolated mouse intestinal villous epithelial cells at 100 µM; dietary administration increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome at 88 mg/kg