RP01357
Recombinant Human TNFRSF4/OX40/CD134 Protein
ABclonal
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DESCRIPTION
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
DETAILS
- Tag: C-His
- Source: HEK293 cells
- Gene Id: 7293
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P43489
- Research Areas: Immune Checkpoint,Bio-Markers & CD Antigens,TNF family,Biosimilar Drug Targets
- Alternative Names: TNFRSF4,ACT35,CD134,IMD16,OX40,TXGP1L