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29113

Methylcobalamin

Cayman Chemical

- Open Babel Depiction N H N _ H 3 C 3+ Co _ N H 3 C O O CH 3 CH 3 N O NH 2 O O _ O P O H OH OH O N CH 3 H 3 C H 3 C O H 2 N H 3 C O H 2 N N H 3 C H NH 2 H 3 C H 3 C N O NH 2 H 3 C O H 2 N

DESCRIPTION

An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer

DETAILS

  • Inchi: InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56+,57+,59-,60+,61+,62+;;/m1../s1
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Natural Products|Vitamins||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Neuroscience|Neurodegenerative Disorders|Amyotrophic Lateral Sclerosis||Research Area|Neuroscience|Pain Research
  • Smiles: [CH3-][Co+3]123([N]4=CN([C@@H](O[C@H](CO)[C@H]5O[P]6([O-])=O)[C@]5([H])O)C7=C4C=C(C)C(C)=C7)[N]8=C9[C@@H](CCC(N)=O)[C@@](CC(N)=O)(C)[C@]8(C)[C@@]([C@H](CC(N)=O)[C@]%10(CCC(NC[C@@H](C)O6)=O)C)([H])[N-]1C%10=C(C)C([C@@H](CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N]3C([C@@](C)(CC(N)=O)[C@@H]%12CCC(N)=O)=C9C
  • Inchikey: ZFLASALABLFSNM-WDJKBINPSA-L
  • Cas Number: 13422-55-4
  • Formulation: A crystalline solid
  • Item Origin: Bacterium/Pseudomonas denitrificans
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C63H91CoN13O14P
  • Formula Weight: 1344.4
  • Shelf Life Days: 1460
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