IT1-H82W5-25ug IT1-H82W5-200ug
Biotinylated Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, Tag Free&His,Avitag™
ACROBiosystems
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DESCRIPTION
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
DETAILS
- Tag: Native | C-10×His & C-Avi
- Host: HEK293
- Size: 200ug
- Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
- Format: Powder
- Purity: 90%
- Source: Biotinylated Human ITGA7X2B&ITGB1 Heterodimer Protein, Tag Free&His,Avitag (IT1-H82W5) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)).
- Storage: -20℃
- Category: MABSol® Biotin Labeled Proteins
- Molecule: Integrin isoform alpha-7X2B beta 1
- Accession: NP_002197.2 (ITGA7X2B) & NP_002202.2 (ITGB1)
- Conjugate: Biotin-labeled
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1)
- Swiss-prot: Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)
- Package Size: 200ug*1
- Characteristics: Biotinylated Human ITGA7X2B & ITGB1 Heterodimer Protein, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.9 kDa (ITGA7X2B) and 86.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail but no tag at the C-terminus and subunit ITGB1 contains a basic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™). The non-reducing (NR) protein migrates as 100-115 kDa due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 116.9 kDa (ITGA7X2B) & 86.7 kDa (ITGB1)
- Shipping Condition: RT
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html