E0135Hu
Human Stem Cell Factor/Mast Cell Growth Factor, SCF/MGF ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
DETAILS
- Gene Id: 4254
- Uniprot: P21583
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 2.52pg/ml
- Detection Range: 5-1800pg/ml
- Detection Method: ELISA
- Species Reactivity: Human