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36-2230-20 36-2230

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody(Clone: ERBB2/3080)

Abeomics

DESCRIPTION

Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

DETAILS

  • Gene: ERBB2
  • App Id: IHC
  • Gene Id: 2064
  • Isotype: Mouse IgG2b, kappa
  • Clone Name: ERBB2/3080
  • Uniprot Id: P04626
  • Host Animal: Mouse
  • Clonality Id: Monoclonal
  • Reactivity Id: Human
  • Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Alternative Name: p185, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog
  • Application Note: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes);
  • Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
  • Immunogen Information: Recombinant human HER-2 protein fragment (around aa 311-462) (exact sequence is proprietary)