DESCRIPTION

• Form: Protein G Purified
• Gene: THRA
• Host: Mouse
• Rrid: AB_2492260
• Type: Primary Antibody
• Clone: 2103
• Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Target: Thyroid Hormone Receptor, α1/α2-Isotype
• Isotype: IgG1
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Synonyms: c-erbA-1 antibody, C-erbA-alpha antibody, EAR-7 antibody, ERBA 1 antibody, ERBA antibody, ERBA related 7 antibody, Nuclear receptor subfamily 1 group A member 1 antibody, THA_HUMAN antibody, THRA antibody, Thra1 antibody, Thra2 antibody, Thyroid hormone receptor alpha 1 antibody, Thyroid hormone receptor alpha 2 antibody, Thyroid hormone receptor alpha antibody, TR alpha 1 antibody, TR alpha 2 antibody, Tra1 antibody, Triiodothyronine receptor antibody, V-erbA-related protein 7 antibody
• Clonality: Monoclonal
• Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, α1/α2-isotype, conjugated to keyhole limpet hemocyanin (KLH).
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for endogenous levels of the ~50 kDa TR-α1 and the ~58 kDa TR-α2 proteins.
• Applications: WB
• Ncbi Gene Id: 7067
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Quality Control: Western blots performed on each lot.
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 50/58
• Production Notes: Protein G purified culture supernatent.
• Dilution Range Wb: 1:1000
• Immunogen Species: Human
• Species Reactivity: Human and Rat
• Target Description: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
• Expected Reactivity: Canine, Mouse, Non-Human Primate
• Dilution Range Wb Brain: 1:1000
• Uniprot Number Immunogen Species: P10827

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