ZAP70 Antibody (Center Y292) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 7535
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ZAP70
Other Names: Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Availability: 2 weeks
Bio Background: This gene encodes an enzyme belonging to the proteintyrosine kinase family, and it plays a role in T-cell developmentand lymphocyte activation. This enzyme, which is phosphorylated ontyrosine residues upon T-cell antigen receptor (TCR) stimulation,functions in the initial step of TCR-mediated signal transductionin combination with the Src family kinases, Lck and Fyn. Thisenzyme is also essential for thymocyte development. Mutations inthis gene cause selective T-cell defect, a severe combinedimmunodeficiency disease characterized by a selective absence ofCD8-positive T-cells. Two transcript variants that encode differentisoforms have been found for this gene.
Bio References: Zanotti, R., et al. Am. J. Hematol. 85(7):494-498(2010)Lin, Y.P., et al. Mol. Immunol. 47 (11-12), 2022-2029 (2010) :Liu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10166-10171(2010)Kotaskova, J., et al. J Mol Diagn 12(3):328-334(2010)Trojani, A., et al. Cancer Biomark 6(1):1-9(2010)
Primary Accession: P43403