Recombinant Human IL-1beta

DESCRIPTION

IL-1beta is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1alpha and IL-1beta bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Recombinant Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.

DETAILS

Gene Id: 3553
Uniprot: P01584
Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 10^9 units/mg.
Category: RUO Cytokines
Subcategory: Growth Factors & Cytokines
Research Areas: Angiogenesis/Cardiovascular, Bone, Skeletal, Cartilage, Cancer, Diabetes/Weight Regulation, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Wound Healing, Allergy, Transplantation, COVID-19
Alternative Names: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Species of Origin: Human
Expression System Source: E.coli