BP18872b
PTEN Antibody (C-term Y315) Blocking Peptide
Abcepta
DETAILS
- Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
- Gene Id: 5728
- Category: Peptides; Blocking Peptides
- Subtitle: Synthetic peptide
- Gene Name: PTEN
- Other Names: Phosphatidylinositol 3,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
- Availability: 2 weeks
- Bio Background: This gene was identified as a tumor suppressor that ismutated in a large number of cancers at high frequency. The proteinencoded this gene is a phosphatidylinositol-3,4,5-trisphosphate3-phosphatase. It contains a tensin like domain as well as acatalytic domain similar to that of the dual specificity proteintyrosine phosphatases. Unlike most of the protein tyrosinephosphatases, this protein preferentially dephosphorylatesphosphoinositide substrates. It negatively regulates intracellularlevels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKBsignaling pathway.
- Bio References: Miletic, A.V., et al. J. Exp. Med. 207(11):2407-2420(2010)Kini, V., et al. J. Biol. Chem. 285(43):33082-33091(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Molina, J.R., et al. Cancer Res. 70(17):6697-6703(2010)Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)
- Primary Accession: P60484