NF kappa B Antibody(Center S276) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5970
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RELA
Other Names: Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Availability: 2 weeks
Bio Background: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
Bio References: Cho, H.H., et al. J. Cell. Physiol. 223(1):168-177(2010)Lu, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(1):46-51(2010)Thoms, H.C., et al. Cancer Res. 70(1):139-149(2010)Rajaiya, J., et al. Mol. Vis. 15, 2879-2889 (2009)
Primary Accession: Q04206