IP-10/CXCL10, Human

DESCRIPTION

IP-10/CXCL10 also known as CXCL10, is originally identified as an IFN-γ-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1β, TNF-α, IL-12 and viruses. Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10.

DETAILS

Form: Lyophilized
Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Species: Human
Product Line: Chemokines
Expression System: E. coli
Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Biological Activity: ED50 < 0.2 μg/ml, measured by a cell proliferation assay of HUVEC cells in the presence of 2.5 ng/ml h-VEGF, corresponding to a specific activity of > 5.0 × 103 IU/mg.
Protein Construction: Expressed with an N-terminal Met. CXCL10 (Val22-Pro98)\nAccession # P02778