29690
SKA-31
Cayman Chemical
DESCRIPTION
An activator of KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay); blocks Kv1.3, -1.5, -3.1, and -3.2 by 10-30% and Nav1.2, -1.4, and -1.5 by 9-40% in a panel of 13 ion channels at 25 µM; increases acetylcholine-induced vasodilation in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM); decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice at 30 mg/kg
DETAILS
- Inchi: InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation
- Smiles: NC1=NC2=C(S1)C=CC3=CC=CC=C32
- Inchikey: FECQXVPRUCCUIL-UHFFFAOYSA-N
- Cas Number: 40172-65-4
- Formulation: A solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C11H8N2S
- Formula Weight: 200.3
- Shelf Life Days: 1460