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E1727Hu

Human Caveolin-1, CAV-1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

May act as a scaffolding protein within caveolar membranes (PubMed: 11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed: 19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed: 17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292).

DETAILS

  • Gene Id: 857
  • Uniprot: Q03135
  • Lead Time: 3 days
  • Assay Type: Sandwich
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.151ng/ml
  • Detection Range: 0.3-90ng/ml
  • Detection Method: ELISA
  • Species Reactivity: Human