Phospho-c-Fos (Ser32) (Clone: BA9) rabbit mAb

DESCRIPTION

c-FOS belongs to the Fos family of nuclear oncogenes which include Fos B, Fos-related antigen 1 (FRA1), Fos-related antigen 2 (FRA2) in addition to c-Fos(1). Activator Protein-1 (AP-1) is formed upon dimerization of Fos proteins with Jun protiens (c-Jun, Jun B, and JunD)(2,3). AP-1 is considered a transcription factor that binds to TRE/AP-1 elements and activates transcription. ERK5 is involved with c-Fos phosphorylation at Ser32 and Thr232 which increase c-Fos stability and its nuclear translocation.

DETAILS

App Id: FACS
Isotype: Rabbit IgG1k
Format Id: Purified
Clone Name: cFosS32-BA9
Host Animal: Rabbit
Clonality Id: Monoclonal
Conjugate Id: Unconjugated
Reactivity Id: Human, Mouse, Rat
Product Content: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Alternative Name: Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, G0S7
Application Note: 1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)
Storage Condition: Store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A synthetic phospho-peptide corresponding to residues surrounding Ser32 of human phospho c-Fos