mouse monoclonal IgG2a; Bcl-rambo Antibody (G-9) is an IgG2a κ mouse monoclonal Bcl-rambo antibody (also designated BCL2L13 antibody, or MIL1 antibody) that detects the Bcl-rambo protein of mouse, rat and human origin by WB, IP, IF and ELISA. Bcl-rambo Antibody (G-9) is available as both the non-conjugated anti-Bcl-rambo antibody form, as well as multiple conjugated forms of anti-Bcl-rambo antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.