DESCRIPTION

• Aa: 2-334(end)
• Mw: 37.5 kDa
• Tags: N-terminal His-tag
• Format: Aqueous buffer solution
• Genbank: NM_017588
• Species: Human
• Uniprot: P61964
• Shiptemp: -80°C (dry ice)
• Synonyms: WDR5, WD Repeat Domain 5, SWD3, BIG-3, Set1c WD40 Repeat Protein, BMP2-Induced 3-Kb Gene Protein
• Warnings: Avoid freeze/thaw cycles.
• Category: Methyltransferase/Enzymes
• Background: As part of the MLL1/MLL complex, WDR5 is involved in methylation and dimethylation at Lys4 of histone H3, which is a specific tag for epigenetic transcriptional activation. As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. WDR5 may regulate osteoblasts differentiation. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes WDR5 contains 7 WD repeats.
• References: 1. Trievel, R.C., Shilatifard, A. (2009). Nature Struct. Mol. Biol. 16 (7): 678-80. 2. Wang, Y.Y., et al. (2010). Proc. Natl. Acad. Sci. USA 107(2):815-20. 3. Odho, Z., et al. (2010). J. Biol. Chem. 285(43):32967-76
• Description: Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
• Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 
• Product Type: Protein
• Biosafety Level: Not applicable (BSL-1)
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Methyltransferase