RP00120
Recombinant Human ErbB-4/HER4 Protein
ABclonal
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DESCRIPTION
This protein is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 2066
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q15303
- Research Areas: Other Recombinant Protein
- Alternative Names: ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4
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