mouse monoclonal IgG2a; Usherin Antibody (G-6) is an IgG2a κ mouse monoclonal Usherin antibody (also designated Usherin antibody) that detects the Usherin protein of mouse, rat and human origin by WB, IP, IF and ELISA. Usherin Antibody (G-6) is available as both the non-conjugated anti-Usherin antibody form, as well as multiple conjugated forms of anti-Usherin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Usherin is a membrane glycoprotein mainly expressed in all capillary and structural basement membranes of the retina and inner ear. It is also found in the spleen, oviduct, epididymis, testis and intestines. Usherin is crucial for inner ear and retina development and also also functions to maintain homeostasis in many other organs. Fibronectin interacts with the LE domain of Usherin in retinal basement membranes and Collagen IV stabilizes Usherin in testicular basement membranes. Mutations in Usherin have been associated with Usher syndrom type IIa, characterized by moderate to severe congenital sensorineural hearing loss with retinitis pigmentosa. These symptoms are caused by the disruption of hair bundle links-mediated adhesion forces that are crucial for the correct organization of growing hair bundles.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.