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116812-10MG

Scientist.com Supplier

ADENOSINE 3' 5'-CYCLIC MONOP 1PC X 10MG (C15-1293-467)

Cen-Med Enterprises

DESCRIPTION

General descriptionCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC50 = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC50 = 25 µM).Biochem/physiol ActionsCell permeable: yesPrimary TargetProtein kinase A and protein kinase GProduct does not compete with ATP.Reversible: noTarget IC50: 900 nM against cGMP-specific phosphodiesteraseWarningToxicity: Standard Handling (A)ReconstitutionFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°COther Notesde Rooij, J., et al. 1998. Nature.396, 474.Kawasaki, H., et al. 1998. Science.282, 2275.Moed, P.J., et al. 1993. Comp. Biochem. Physiol.105A, 711.Connolly, B.J., et al. 1992. Biochem. Pharmacol.44, 2303.Phillips, M.E., and Taylor, A. 1992. J. Physiol.456, 591.Shipston, M.J., and Antoni, F.A. 1992. Endocrinology130, 2213.Datta, R., et al. 1991. Blood78, 83.Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA88, 9219.Sandberg, M., et al. 1991. Biochem. J.279, 521.Unterman, T.G., et al. 1991. Endocrinology128, 2693.Xu, H., et al. 1989. Brain Res.504, 36.Legal InformationCALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

DETAILS

  • Category: Radiochemicals/Labeled Compounds/Radiolabeled Cyclic Nucleotides
  • Unspsc Code: 12142207

MANUFACTURER

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