1984764-250mg 1984764-100mg
Tranylcypromine hydrochloride
Biogems
DESCRIPTION
Tranylcypromine hydrochloride is a cell-permeable inhibitor of histone demethylzation. It is reported to be an irreversible inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1. It is also useful in chemically reprogramming murine fibroblasts to induced pluripotent stem cells.
DETAILS
- Purity: ≥98%
- Synonyms: Parnate, (1R,2S)-rel-2-phenylcyclopropanamine monohydrochloride, Tranylcypromine hydrochloride, 2-PCPA
- Cas Number: 1986-47-6
- References: Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., ... & Deng, H. (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 341(6146), 651-654. Zhou, H., Li, W., Zhu, S., Joo, J. Y., Do, J. T., Xiong, W., ... & Ding, S. (2010). Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. Journal of Biological Chemistry, 285(39), 29676-29680. Schmidt, D. M., & McCafferty, D. G. (2007). trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.Biochemistry, 46(14), 4408-4416.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: trans-2-Phenylcyclopropylamine hydrochloride
- Molecular Weight: 169.7
- Molecular Formula: C9H11N HCl
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1C(C1N)C2=CC=CC=C2.Cl