39-2014
Anti-Alkaline Phosphatase Polyclonal Antibody
Abeomics
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DESCRIPTION
Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney(tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine(PEA) and pyridoxal-5-prime-phosphate(PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.
DETAILS
- Gene: Alpl
- App Id: WB
- Antigen: Alkaline phosphatase, tissue-nonspecific isozyme
- Gene Id: 25586
- Isotype: Rabbit IgG
- Format Id: Lyophilized
- Uniprot Id: P08289
- Host Animal: Rabbit
- Clonality Id: Polyclonal
- Purification: Immunogen affinity purified.
- Reactivity Id: Rat
- Product Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Alternative Name: Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; 3.1.3.1; Alkaline phosphatase liver/bone/kidney isozyme; Alpl
- Application Note: Western blot : 0.1-0.5µg/ml
- Storage Condition: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Immunogen Information: A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase(18-32aa, FVPEKEKDPSYWRQQ), different from the related mouse sequence by one amino acid.