Theaflavin 3,3'-digallate

DESCRIPTION

A polyphenol with diverse biological activities; inhibits the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively); reduces hydroxyl radical-induced damage to plasmid DNA; prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells from 12.5-50 µM; reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury; inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro; reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice

DETAILS

Inchi: InChI=1S/C43H32O20/c44-17-7-23(46)21-12-33(62-42(58)15-3-25(48)36(54)26(49)4-15)40(60-31(21)9-17)14-1-19-20(11-30(53)39(57)35(19)38(56)29(52)2-14)41-34(13-22-24(47)8-18(45)10-32(22)61-41)63-43(59)16-5-27(50)37(55)28(51)6-16/h1-11,33-34,40-41,44-51,53-55,57H,12-13H2,(H,52,56)/t33-,34-,40-,41-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
Smiles: O=C1C2=C(O)C(O)=CC([C@@H]3[C@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)CC(C(O)=CC(O)=C5)=C5O3)=C2C=C([C@H]6OC(C=C(O)C=C7O)=C7C[C@H]6OC(C8=CC(O)=C(O)C(O)=C8)=O)C=C1O
Inchikey: ZEASWHWETFMWCV-ISBUVJFSSA-N
Cas Number: 30462-35-2
Formulation: A crystalline solid
Item Origin: Plant/Black Tea
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C43H32O20
Formula Weight: 868.7
Shelf Life Days: 1460