T75436
Jatrorrhizine hydroxide
TargetMol
DESCRIPTION
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 value of 872 nM, demonstrating over 115-fold greater selectivity for AChE compared to butyrylcholinesterase (BuChE) [2]. Additionally, Jatrorrhizine hydroxide impedes the uptake of serotonin (5-HT) and norepinephrine (NE) by inhibiting uptake-2 transporters, further contributing to its pharmacological profile [3].
DETAILS
- Cas: 483-43-2
- Purity: 98%
- Category: Compound
- Molecular Weight: 355.38
- Molecular Formula: C20H21NO5
Lead Time: 4 - 5 weeks
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