T4010
Juglone
TargetMol
DESCRIPTION
Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
DETAILS
- Cas: 481-39-0
- Purity: 98.73%
- Smiles: Oc1cccc2C(=O)C=CC(=O)c12
- Category: Compound
- Molecular Weight: 174.15
- Molecular Formula: C10H6O3
Lead Time: < 1 week
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