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Human Presenilin 2, PS-2 ELISA Kit

Bioassay Technology Laboratory


Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed: 16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed: 21285369).


  • GeneID: 5664
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 50,140
  • Synonyms: AD3LP;AD5;E5-1;Presenilin-2;Presenilin-2 CTF subunit;Presenilin-2 NTF subunit;PS-2;PSEN 2;PSEN2;STM-2
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: PSEN2
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 2.47ng/L
  • Target Protein: PSEN2
  • Detection Range: 5-1000ng/L
  • Full Product Name: Presenilin 2
  • Standard Solution: 1280ng/L
  • UniProt Accession: P49810