mouse monoclonal IgG1; Troponin I-C Antibody (G-11) is an IgG1 κ mouse monoclonal Troponin I-C antibody (also designated Troponin I-C antibody or Troponin antibody) that detects Troponin I-C of human origin by WB, IP, IF and ELISA. Troponin I-C Antibody (G-11) is available as the non-conjugated anti-Troponin I-C antibody form, as well as multiple conjugated forms of anti-Troponin I-C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer composed of two heavy chains (MHC) and four light chains (MLC); it interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin comprises at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and Troponin T (the link to the muscle thin filament). Troponin C is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Troponin C has two isoforms: fast and slow. Fast Troponin C has two calcium binding sites while slow/cardiac Troponin C has a single calcium binding site.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.