mouse monoclonal IgG1; MIC2 Antibody (12E7) is an IgG1 κ mouse monoclonal MIC2 antibody (also designated MIC2 antibody) that detects the MIC2 protein of human origin by WB, IP, IF and IHC(P). MIC2 Antibody (12E7) is available as both the non-conjugated anti-MIC2 antibody form, as well as multiple conjugated forms of anti-MIC2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. MIC2, also designated CD99, is a T cell surface protein that is involved in the aggregation of lymphocytes. Two forms of MIC2, which are differentially expressed, are produced by alternative splicing. The major form induces cellular adhesion, whereas the truncated form inhibits the adhesion process. MIC2 regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes. Overexpression of the truncated form results in downregulated expression of LFA-1. Cells with downregulated MIC2 exhibit a Hodgkin's and Reed-Sternberg (H-RS) phenotype, indicating that MIC2 plays an important role in regulating cell function and morphology.