E2F1 Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1869
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: E2F1
Other Names: Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3
Availability: 2 weeks
Bio Background: E2F1 is a member of the E2Ffamily of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressorproteins and is also a target of the transforming proteins of smallDNA tumor viruses. The E2F proteins contain several evolutionallyconserved domains found in most members of the family. Thesedomains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulatedtranscription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor proteinassociation domain which is embedded within the transactivationdomain. This protein and another 2 members, E2F2 and E2F3, have anadditional cyclin binding domain. This protein binds preferentiallyto retinoblastoma protein pRB in a cell-cycle dependent manner. Itcan mediate both cell proliferation and p53-dependent/independentapoptosis.
Bio References: Pulikkan, J.A., et al. Blood 115(9):1768-1778(2010)Paik, J.C., et al. J. Biol. Chem. 285(9):6348-6363(2010)Alla, V., et al. J. Natl. Cancer Inst. 102(2):127-133(2010)Helin, K., et al. Cell 70(2):337-350(1992)
Other Accession: NP_005216
Primary Accession: Q01094