Phospho-MDM2(S166) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4193
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MDM2
Other Names: E3 ubiquitin-protein ligase Mdm2, 632-, Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2, MDM2
Availability: 2 weeks
Bio Background: MDM2 is a target of the transcription factor tumor protein p53. It is a nuclear phosphoprotein that binds to and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor proteinp53, diminishing its tumor suppressor function. This protein has E3ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. It also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Bio References: Burch, L.R., et al., J. Mol. Biol. 337(1):115-128 (2004).Schon, O., et al., J. Mol. Biol. 336(1):197-202 (2004).Mantesso, A., et al., J. Oral Pathol. Med. 33(2):96-101 (2004).Shmueli, A., et al., Mol. Cell 13(1):4-5 (2004).Xia, L., et al., Cancer Res. 64(1):221-228 (2004).
Primary Accession: Q00987
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3501a was selected from the region of human Phospho-MDM2-pT166. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.