Anti-AMPK alpha 2 Antibody [A6A10]

DESCRIPTION

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

DETAILS

Host: Mouse
Type: Primary
Uniprot: SwissProt: P54646 Human;SwissProt: Q8BRK8 Mouse;SwissProt: Q09137 Rat
Clone Id: A6A10
Clonality: Mouse monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: 5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody AAPK2_HUMAN antibody ACACA kinase antibody Acetyl CoA carboxylase kinase antibody Acetyl-CoA carboxylase kinase antibody AMPK alpha 2 chain antibody AMPK subunit alpha-2 antibody AMPK2 antibody AMPKa2 antibody AMPKalpha2 antibody HMGCR kinase antibody Hydroxymethylglutaryl CoA reductase kinase antibody Hydroxymethylglutaryl-CoA reductase kinase antibody PRKAA antibody PRKAA2 antibody Protein kinase AMP activated alpha 2 catalytic subunit antibody Protein kinase AMP activated catalytic subunit alpha 2 antibody
Application: WB,IF-Cell,IHC-P
Epitope Region: Recombinant protein within human AMPK alpha 2 aa 231-430.
Protein Target: PRKAA2
Target Species: Human,Mouse,Rat
Species Reactivity: Human,Mouse,Rat