Casein Kinase Iα (phospho Thr321) rabbit pAb

DETAILS

Isotype: IgG
Category: Antibody
Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Clonality: Polyclonal
Immunogen: The antiserum was produced against synthesized peptide derived from human Casein Kinase I alpha around the phosphorylation site of Tyr321. AA range:287-336
Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
Reactivity: Human;Mouse;Rat
Applications: WB;IHC;IF;ELISA
Concentration: 1 mg/ml
Human Gene Id: 1452
Observed Bandkd: 35kD
Alternative Names: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1
Storage Stability: -20°C/1 year
Human Swiss Prot No: P48729
Subcellular Location: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). .