SPR-465B SPR-465C SPR-465E
Transthyretin Y78F Variant Filaments
Stressmarq Biosciences
DESCRIPTION
Human Recombinant Transthyretin Y78F Variant Protein Filaments
DETAILS
- Nature: Recombinant
- Purity: >95%
- Target: Transthyretin (TTR)
- Category: Protein
- Conjugate: No Tag
- References: 1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Terazaki H.,m et al. (2006) Lab Invest. 86(1): 23-31.
- Applications: WB | SDS-PAGE | In vivo assay | In vitro assay
- Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Protein Size: 15.887 kDa
- Purification: Ion-exchange Purified
- Concentration: Lot/batch specific. See included datasheet.
- Protein Length: Full length
- Research Areas: Neuroscience | Neurodegeneration | Alzheimer's Disease | ALS Disease | Tangles & Tau | Parkinson's Disease | Cardiovascular System | Blood | Cell Signaling | Metabolism | Lipid and lipoprotein Metabolism
- Storage Buffer: PBS pH 7.4
- Alternative Names: Amyloid polyneuropathy Protein, Amyloidosis I Protein, ATTR Protein, Carpal tunnel syndrome 1 Protein, CTS Protein, CTS1 Protein, HEL111 Protein, HsT2651 Protein, PALB Protein, Prealbumin Protein, Prealbumin amyloidosis type I Protein, Prealbumin Thyroxine-binding Protein, TBPA Protein, Thyroxine binding prealbumin Protein, Transthyretin Protein, TTHY_HUMAN Protein,TTR Protein
- Cite This Product: Human Recombinant TTR Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-465B)
- Expression System: E. coli
- Species Full Name: Human
- Storage Temperature: -80ºC
- Shipping Temperature: Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
- Cellular Localization: Cytoplasm | Extracellular exosome | Extracellular Region | Lysosome
- Scientific Background: Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
- Certificate of Analysis: Certified >95% pure using SDS-PAGE analysis.
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