mouse monoclonal IgG1; WHIP Antibody (G-2) is an IgG1 κ mouse monoclonal WHIP antibody (also designated WHIP antibody) that detects the WHIP protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. WHIP Antibody (G-2) is available as both the non-conjugated anti-WHIP antibody form, as well as multiple conjugated forms of anti-WHIP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Werner's syndrome is an inherited, autosomal recessive disorder that is characterized by premature aging and commonly results in cancer. WHIP, also known as WRNIP1 (Werner helicase-interacting protein 1) is a ubiquitously expressed member of the AAA ATPase family that is involved in the regulation of DNA synthesis. Localized to the nucleus, WHIP acts as a modulator for initiation events during DNA polymerase-mediated DNA synthesis and, through its ATPase activity, can detect DNA damage or arrested replication forks. WHIP is found in granular structures within the nucleus, where it interacts with the N-terminal domain of WRN, the protein product of the gene responsible for Werner's syndrome. Due to its close association with WRN, WHIP is thought to be involved in the aging process and thus may play a role in the development of Werner's syndrome. Four isoforms of WHIP are produced due to alternative splicing events.